Just tried this out.
Cons:
Search has some really nasty lag when you type into it
Closing the craftguide window also closes any other GUI you had open (such as inventory or crafting table)
Some of the machine interface simulations are really... off.
Pros:
Support for forestry 2.0 without a plugin (which currently isn't available for NEI)
Fixed my inventory lag that was apparently being caused by NEI
Don't have to click through 100 single-item pages to get different recipes
It's going to take some getting used to, but I definitely think I'll try to stick with this.
edit: looks like it's missing microblocks and assembly table support, but that's no big deal. All the microblocks were just wasted space in NEI anyway since every block type uses the same recipe, and the assembly table recipes are simple enough and all shapeless.