Sounds like the new gregtech is maybe top end uranium numbers without the high running costs. Something in the 50 million per ingot range, but with some fuel usage scenarios not actually being much better than uranium.
Ignoring cost to build for a moment would you get more out of each ingot running plutonium+thorium or eff 7 iridium reflector quad uranium?
To be relevant plutonium+thorium should beat that usage scenario, but i don't think it does, which is why i left it off my personal 1.5.1 pack.
That's pretty much what my math is trying to answer, yes - the efficiency number it computes is directly comparable with uranium. So the hybrid reactor in post #288 with its efficiency of 7.76 does beat the 7.00 of quad uranium surrounded by reflectors.
Except for the fact that that reactor doesn't work, as I just discovered in my test world today. The cooling system relies on the fact that the overclocked vent in the lower right corner cannot pull enough heat from the reactor to melt itself down, because no more heat is left to be pulled. Unfortunately the actual game doesn't work that way. You still get one vent that isn't under full load, but it's not the one in the lower right corner. Instead it's one randomly somewhere in the middle or top. I don't begin to understand how and why the reactor planner is simulating things wrong, but the net result is that the design as posted is not stable. If anyone wants to try their hand at making it stable, please share your results.
However, you definitely do beat uranium surrounded by reflectors if you simply use pure plutonium or thorium and surround that with reflectors. Quad plutonium is completely uncoolable with internal vents in all scenarios where it has more than two neighbours (and only very few work with two), but you can get dual plutonium in a 4-neighbour situation just fine. If you look into my spreadsheet, you can see some theoretical comparisons between uranium and plutonium/thorium centrifuge output in different neighbour configurations. Overall you can get more output if you centrifuge your isotopes and run them in the same reflector configurations as you would if you used uranium.
Case in point, let's do some math: one dual plutonium cell with 4 reflectors, and two quad thorium cells with 4 reflectors each (you said to ignore build cost, after all :P). You'll get 64 million + 14 million + 14 million EU, equals 92 million. For the same 10 isotopes, you could have two and a half quad uranium cells surrounded by reflectors, which would pull 28 + 28 + 14 = 70 million. So a 22 million EU advantage in a scenario that could conceivably happen in practical application. Plutonium doesn't do as good as expected here because you cannot use quad cells for heat reasons and thus it isn't running at maximum efficiency. Still, efficiency 9.2 isn't half bad.
Also you can reach reflector-like efficiencies without paying the huge cost associated with reflectors. The multi-reactor system I am planning for my next world will do efficiency 6.84 without using a single reflector. Granted, all those reactors aren't exactly cheap either, but they won't cost me emeralds and they do output a total of 1,368 EU/t all together And there is no CRCS involved, just internal vents. I bet if you tried to beat that kind of EU/t and efficiency with just uranium and reflectors, you'd be paying a lot more than I will be.
EDIT: And that's going to be a system built to look cool. If you aim for maximum efficiency you can go higher with a multi-reactor system, even without reflectors.