Some time ago scientists thought of the idea of making gold from lead by taking some protons and electrons away (I could be wrong but whatever...). This could be achieved by using a particle collider (The cost of using the particle collider outweighed the profits...)
That has been done already, but never on any bigger scale, as it isn't economically feasible. You don't even need a particle collider for that, you can radiate platinum or a specific mercury isotope that makes up 0.15% of natural mercury. I'm sure you are aware that neither of those ways would make any sense whatsoever, neither in real life nor in the game, and not only because you would need a breeder reactor and because the process would be terribly slow.