The design inside the reactor is here (taken from this thread in fact, I believe. I am shamelessly stealing this design).
I tried getting it down to a two chamber reactor, but I am having issues cooling it.
Efficiency and number of chambers (for stackability) are my prime considerations, let me know what you guys think.
Well, that was a refreshing challenge, thanks Here you go! 10% more copper-hungry than the 3-chamber variant, but it should fit your need perfectly.
I'm using FTB Unhinged, which is MC 1.5.2 and GT 3.11. I want to have a different design for uranium, and reading through the thread, I found this, but it appears to be for an older version, as my results in game on a Gregtech computer are very different. Not unstable, just way less power.
So, my question is, what's an efficient use for plutonium now? I had planned on squeezing every bit of efficiency out of it as I could, in one or two 6 chamber designs, but everything I design in game has terri-bad output.
The hybrid reactors like the one you linked posted the numbers they did because of a bug in GregTech in 1.4.7. It was fixed in v2.90+. After trying some alternative scaling systems in the early 3.0x versions, Greg ultimately settled on returning the values to something similar to 1.4.7, just without the hybrid bug and with minimally reduced heat. He said he can't do what he wants with the current ractor system and instead postponed toying with it until a future total revamp (which, incidentally, seems to now be coming in base IC2's experimental branch). You can see the values appropriate for your GregTech version in my spreadsheet.
There's a few things you can do now - the pride of my work, for example, is an uranium/plutonium hybrid with an insane 720 internal cooling, together with a so-called thorium sink reactor that just tries to burn through the gigantic amounts of thorium that you get on the side as fast as it can. With the plutonium hybrid at +32T/20k and the sink at -36T/25k, the thorium balance isn't perfect - you'll generate sightly more thorium than you can consume. But you could let the plutonium reactor skip a cycle here and there to let the thorium sink catch up. The pair runs at 360 + 204 EU/t when both are active, and if all thorium is consumed it posts an incredible isotope efficiency of 5.831, which is more than a full number above the best of uranium reactors.
The downside of course being that you now have a pair of six-chamber reactors that really can't be stacked in close quarters. But you could use the same concept to implement a smaller, more modular multi-reactor system, or try to build a singular thorium-neutral thorium/plutonium hybrid of a stackable size. The online reactor planner won't help you much with that, as it reports the wrong EU/t and the wrong heat values for hybrid systems, but it can still be used to design cooling systems with a more comfortable interface than the computercube.
In general, uranium is slightly more suitable for high EU/t numbers, while plutonium lends itself a little better for high efficiency builds. The plutonium hybrid I have up there is actually on the low end of the efficiency spectrum, with two single-neighbor quad cells... I just wanted to cram as much output as I could into a mere three fuel cell slots, while also making use of that gigantic cooling system