Not much of a fan of that metric because it rolls breeding gains into the number, and thus isn't comparable to standard IC2 reactors... you can basically only rate GregTech reactors with that, and then it'll confuse people into thinking they can compare the numbers to pure uranium.
Admittedly isotope efficiency isn't the most straightforward of models, especially with multi-reactor systems, but I wanted to avoid any confusion and keep everything fully comparable. That's why I opted for a metric that exactly returns the reactor planner numbers for pure uranium reactors while also appropriately describing GregTech fuels with the exact same formula. I think that a little complexity is a fair price to pay (but I suppose that as long as there is no automated tool like the reactor planner that reports it, it won't really see widespread adoption).
Just for reference of other readers who may not have seen my previous post, here's how you would calculate isotope efficiency for the multi-reactor system presented in post #364:
First, figure out how many isotopes you require to craft enough fuel for one full cycle. Pick one reactor to start with, usually the plutonium reactor. This example runs one dual uranium cell and 2 quad plutonium cells, and due to lifetime differences, the dual uranium cell must be replaced once per cycle. You effectively have two dual uranium cells, for a total of four uranium and eight plutonium. 1 uranium is 1 isotope, but 1 plutonium is 5 isotopes because the centrifuge turns 5 isotopes into 4 thorium and 1 plutonium. Eight such centrifuge runs thus cost 40 isotopes. Together with the 4 for uranium, that's 44 isotopes to stock the plutonium reactor.
Is this enough to also stock our thorium sink? The runtime for the plutonium reactor is 20,000 seconds, and for each such cycle we have 32 thorium left over. The thorium sink reactor runs for 25,000 seconds, which is one quarter more. During that extra quarter, the plutonium reactor generates an extra 8 excess, for a total of 40. Since we only need 36, we don't need to spend any extra isotopes here.
And now you can also see why explaining things to people is a good thing, because I just noticed that I made a mistake earlier. God dammit why am I so sloppy
Second, determine the total EU generated for one cycle. 360 EU/t for 20,000 seconds, plus 204 EU/t for 25,000 seconds: 144 million + 102 million = 246 million.
Eight runs of the centrifuge cost 800,000 EU, subtract that: 245.2 million. This is also the point where you would subtract running costs for your reactor if you paid them in UU-matter, but since this is a GregTech reactor and thus subject to GregTech's UU-matter costs, that is a pretty silly proposition, so I'll skip it here.
Finally, divide your EU total (in millions) by your invested isotopes: 245.2 / 44 = 5.5727272727272727...
This number is your isotope efficiency. Or, in other words:
"At what efficiency would you be if you generated this much EU out of this number of isotopes using just a pure uranium reactor."
Third, check if there's anything left: our reactor system only consumes 36 out of 40 thorium every 25,000 seconds. The system is thus "+4T/25k" thorium positive. That thorium is free energy we're not yet taking advantage of, so we might want to do that.
Since 4 thorium is 1/9th of the full 36 load of the thorium sink, we'll just say that these 4 will, at some unkown point in time when we have run many cycles and amassed enough thorium to let the sink run a bonus cycle, give us roughly 1/9th the energy output of a full sink cycle. So 102 million EU / 9 = 11.3333333... million EU. We get to add this number to the total EU yield of the reactor system, which rises from 245.2 to 256.533333...
And then just repeat the division: 256.53333333... / 44 = 5.830830830...
Therefore, by utilizing all the thorium, the final isotope efficiency of the system is 5.831.
Sorry guys, not 6.474, I blame food coma for inventing an extra 10 thorium that wasn't there.