MOX works exactly like uranium. The behavior in the reactor is the same in every aspect.
The only thing that changes is the EU/t output as an additional step after the primary calculation, based on the percentage of hull heat the reactor has. The fuel rods inside don't change. They still perform as they always did. They do not suddenly change efficiency or output more heat than before or anything like that - they simply gain an additional bonus that's independent from anything else. Any design that is safe with uranium is also safe with MOX. However, if you want to maintain a high hull heat level, you will run into troubles with components that exchange heat with the hull (and the fact that almost all common uranium designs force the fuel rods themselves to exchange heat with the hull).
What you'll want to do is read Alblaka's reactor overview (and I mean read, don't skim or TL;DR) so you understand how components and fuel rods behave in certain situations. Best grab the reactor planner and try to see it in action. Then when you're firm on that, read about MOX reactors. Useful designs start cropping up after the bugfixes on page 2, but the earlier posts also discuss some theory that you might want to check out.