First, I'd like to present to you a picture, just so you can see how compact this design is:
Looks awesome, doesn't it? Let's go over what it has, why it has it, and how easy it is to automate.
Now, there's two other mods in play here. The first is Applied Energistics. Attached to each reactor, there's a Fuzzy Import Bus and a Fuzzy Export Bus. The Fuzzy Import Bus automatically pulls the proper nuclear material into the reactor, and the fuzzy export bus automatically pulls out all depleted cells. This means full automation of nuclear material. This reactor design never needs to stop for a moment, assuming you need that much consistent power draw.
Second is MFR. You see that red cabling in the corner? That's Rednet Cable. Among other things, it functions much like Red Wiring, in that it will transmit a redstone signal as long as you have the cable connected. Actually, it's more like Bundled Cable in that it can transmit up to 16 different color coded signals simultaneously, with no server lag because of no block updates, but we aren't using that functionality here.
Now then, what you are seeing is ten segments of a ring of four Pocket Reactors. Each one produces 180 EU/t. In the center is the glass Fibre cable that runs to the MFSU behind the ME Control Unit. Obviously, the wiring can really go anywhere, I'm just testing this system out for viability.
As you can see, this thing actually has a smaller footprint than most CRCS designs, and it is vertically modular, meaning you can literally build it as high as you like, keeping in mind the slight EU loss from the glass fibre cable for distances over 40 blocks.
Basically, it's built like an old-school water tower, but it doesn't need a gap between segments for water, so it's even more space efficient. And at 720 EU/t per segment, it's got significantly more power output. It also fits in a 5 x 5 square hole, as deep as all attached segments plus two.
This is a Mk. I setup, so it needs no cooldown. Hook it up to an autocrafting module and tell it to keep the twin uranium cells in stock, and this baby can run indefinitely. Best of all, it automatically pulls all of the depleted uranium cells, which can then be auto-crafted into re-enriched isotope cells, and if the ME network is hooked up to a breeder, can even automatically inject them into the breeder for your convenience.
Much as it pains me to admit... this modular design pretty much kills CRCS, except in marginal cases where you want a higher Efficiency value (CRCS reactors tend to have a 5-6 efficiency rating, whereas this only has 3).
But wait... it gets better...
Did you know you can do this with two-chamber reactors? Sure, it increases the radius of the square by one, but entirely doable. Sure, the costs go up, not sure if it would be cost efficient to do so, but you could theoretically get even more energy out of this design.
In conclusion, the CRCS reactors were an out-of-the-box innovation, but were never really all that cost efficient to begin with. This sort of modular system, however, pretty much beats CRCS reactors on every metric except efficiency.