So, a redstone circuit block. Will this work like a crude FPGA, where you "configure" the gates on the redstone circuit block to implement an overall equation? Doesn't sound like it, but if it worked like an FPGA, you wouldn't need covers.
This would let you create all of the gates from redpower in 1 device, by simply switching the configuration around on this block.
So if that handles circuitry, and immibis has the microblocks taken care of, and AE handles moving items around...
Computercraft handles computers in an overpowered way (basically it needs to be installed along with another mod to make the computers only craftable with phat stacks of resources)
Extra Biomes adds more biomes that are better than volcanos and her rubber trees.
Other mods handle the lighting...what else does this leave?
2 things : signaling (her wires can go on any surface) and frames.
I've been trying to get gregtech to write a warp engine for a while that would let you move a whole volume of blocks somewhere else in one "jump". (and would require fusion power, or a huge number of energy storage blocks, in order to run). It wouldn't directly replace frames, since it would be a lot more expensive and only useful for big stuff (if you wanted to move an entire base or once or have a mining "ship" that gets moved around the world). So if Eloraam ever does update redpower, frames would still have a use. But it means that if in a few weeks from now, it's time to update to 1.51, and Eloraam hasn't ported her mod, it wouldn't be a big deal anymore.
And AlgorithmX2 has said he might write a similar mechanic to said warp drive. It wouldn't quite work this way, instead, you would be able to SAVE an actual 3d structure in the world to a disk (and when you do this, the structure is destroyed), and then go somewhere else and re-instantiate that structure. Sort of how a Star Trek teleporter works, except, you can keep the pattern buffer disk in a chest, you don't have to immediately re-instantiate the structure. You would not be able to copy the structure because of all the issues with duping this potentially creates.
Either way this would add a LOT to the game. Fusion warp drives? You could have your base flying in the air, and have miners of some kind deploy below it. Do all the ore processing, etc, inside your base, and just beam somewhere else when you are done. Saving your base to drive? You could "de-materialize" your base whenever you are done playing for the night and hide it in a chest somewhere, safe from griefers.