When I was running on an MFE, I found that my pair of macerators could only handle 5-6 overclockers before starving themselves - until I installed a storage upgrade and a transformer upgrade in each machine.
Then they were able to handle 8 each and I could also run my other machines at the same time (the induction furnace is a hungry beast). After upgrading to an MFSU/MVT, I'm able to use a dozen overclockers in my machines and everything hums along nicely - each task is completed almost instantly. Sure, it's power-hungry, but my wind farm is almost as effective as a small reactor so it refills the MFSU pretty quickly.
There are still applications for which the Advanced Machines are a better choice, but when you've got endgame-level power generation, you can get more performance from seriously overclocked machines, as long as they have the other upgrades installed.