I did some maths and the reality is: powerful reactors are completely worthless.
The most powerful fluid reactor I could come up(26880HU/s) with is only 133% as powerful as my Melon Power Plant(20480HU/s) while costing several times as much. It's also not more compact.
Granted, the melon power plant costs a lot more tin to build, but in total material value that doesn't matter because replicator is a thing.
As long as the reactor components remain excessively overpriced, nuclear power plants will never be worth it and the only use for uranium that makes sense is a lot of very inefficient reactors for plutonium production.
This also makes lead a lot less useful, because a low-efficiency fluid reactor is a lot worse than a low-efficiency EU reactor.
Is there some big game changer I'm missing or is Uranium really just for depleting ASAP?